Structural　defects　in　graphene　are　inevitable　during　the　production　process,　which　have　remarkable　impacts　on　the　mechanical　properties　of　graphene　and　further　affect　the　properties　of　nanocomposite　reinforced　by　graphene.　In　this　work,　a　bottom-up　multiscale　approach　is　employed　to　investigate　the　nonlinear　dynamics　of　defective　graphene　reinforced　composite　plates　from　the　material　properties　of　nanocomposites　to　the　dynamic　behavior　of　macro-composite　plates.　The　molecular　modeling　and　simulation　are　conducted　by　molecular　dynamics　(MD)　to　evaluate　the　effective　mechanical　properties　of　pristine　graphene,　vacancy　defective　graphene,　Stone-Wales　defective　graphene,　poly　(methyl　methacrylate)　(PMMA)　and　graphene/PMMA　composites　reinforced　by　different　graphene　configurations　at　the　nano-scale.　Meanwhile,　the　fracture　mechanism　and　interfacial　interaction　energy　between　graphene　and　PMMA　matrix　during　the　deformation　process　are　examined　to　explore　the　enhancement　mechanism　of　nanocomposites.　The　efficiency　parameters　are　derived　by　incorporating　the　MD　results　and　the　extended　Halpin-Tsai　micromechanics　model　to　capture　the　heterogeneity　of　nanocomposite　at　the　nano-scale　as　well　as　the　continuum　scale,　and　then　the　effective　material　properties　considering　the　effect　of　defect,　temperature　and　pressure　are　substituted　into　the　nonlinear　dynamics　of　functionally　graded　graphene　reinforced　composite　(FG-GRC)　plates　at　the　macro-scale.　The　governing　equations　of　motion　for　FG-GRC　plates　under　the　aerodynamic　pressure　are　derived　based　on　the　third-order　shear　deformation　theory,　von-Karman　nonlinear　strain-displacement　relation　and　Hamilton＇s　principle.　The　aerodynamic　pressure　acting　on　the　surface　of　the　plate　consists　of　two　parts,　one　is　the　static　pressure,　and　the　other　is　the　disturbed　air　flow.　Furthermore,　Galerkin　method　and　the　fourth-order　Runge-Kutta　method　are　exploited　to　discrete　and　solve　the　governing　equations　of　motion.　The　bifurcation,　time　history　and　phase　diagrams　of　FG-GRC　plates　are　obtained　to　analyze　the　dynamic　characteristics　of　the　plates.　This　study　reveals　the　nonlinear　dynamic　characteristics　of　graphene/PMMA　composite　plate,　which　contributes　to　the　prediction　of　dynamic　response　of　composite　structure　in　the　aerospace　field.