Preparation　of　membranes　with　loose　structure　is　often　required　for　excellent　small　organic　molecules　desalination,　but　remains　a　grand　challenge.　In　this　work,　a　loose　thin　film　composite　(TFC)　membrane　was　fabricated　via　interfacial　polymerization　of　hydroxypropyl-β-cyclodextrin　(HP-β-CD)　and　trimesoyl　chloride.　Besides,　tannic　acid　was　added　in　the　aqueous　phase　to　boost　the　rejection　rate　of　the　membrane　by　reducing　the　“outer　space”　distance　among　HP-β-CD.　The　resulting　membrane　exhibited　an　optimal　permeability　of　82.9　L　m−2h−1　bar−1　along　with　antibiotic　desalination　efficiency　(94.8　%　for　tetracycline　hydrochloride　and　8.5%　for　NaCl).　Moreover,　experiment　results　demonstrate　that　the　tannic　acid　incorporated　HP-β-CD-based　polyester　(TIHP)　membrane　was　also　endowed　with　enhanced　chlorine　resistance　and　antifouling　ability　deriving　from　its　rich　hydroxyl　and　polyester　structures,　which　makes　the　membrane　promising　for　the　purification　of　antibiotics　in　pharmaceutical　fields.　©　2023　Elsevier　B.V.