This　study　proposes　an　evacuation　guidance　model　for　heterogeneous　populations　to　investigate　the　effects　of　guidance　strategies　on　the　evacuation　process　in　large-scale　pedestrian　facilities　with　multiple　exits.　The　guidance　model　integrates　an　exit　choice　model　and　a　microscopic　pedestrian　simulation　model　with　discrete　space　representation.　The　exit　choice　model,　considering　the　travel　distance　to　each　exit,　the　level　of　congestion　and　the　movement　speed　of　pedestrians,　generates　the　allocation　of　exits　to　pedestrians.　The　microscopic　simulation　model　depicts　the　pedestrian　movements　during　the　evacuation　under　guidance.　Numerical　simulations　are　conducted　to　evaluate　the　performance　of　the　guidance　strategy.　Simulation　results　indicate　that　by　balancing　the　time　interval　for　sending　evacuation　instruction　and　the　frequency　of　the　target　exit　changes,　better　evacuation　performance　can　be　achieved.　Comparison　between　two　cases　with　and　without　instruction　reveals　that　the　performance　of　the　guidance　strategy　is　closely　related　to　the　pedestrian　density　level　and　the　heterogeneous　speeds　of　pedestrians.　The　evacuation　performance　is　also　affected　by　the　compliance　behavior　and　non-compliance　behavior　of　pedestrians.　The　findings　can　provide　theoretical　suggestions　for　the　effective　management　of　crowd　movement　at　large　events.　©　2023　Elsevier　B.V.