Polytetrafluoroethylene　(PTFE)　with　good　resistance　can　be　used　under　extreme　conditions,　however,　its　surface　hydrophobicity　greatly　limits　its　wide　application　in　water　treatment　field.　In　this　work,　the　hydrophobic　PTFE　microfiltration　(MF)　membrane　was　innovatively　modified　into　a　hydrophilic　loose　nanofiltration　(NF)　via　synergic　effect　of　the　deposited　polyethyleneimine　(PEI)　and　poly(vinylpyrrolidone)　(PVP)　with　assistance　of　fluorocarbon　surfactant　(FCS),　and　then　crosslinked　by　glutaraldehyde　(GA).　The　surface　morphology,　porosity　and　aperture　size　of　the　obtained　cPEI-PVP-FCS/PTFE　(cPPF)　membrane　were　characterized　in　detail.　The　resultant　membrane　showed　good　dye　desalination　performance　with　high　Evans　blue　rejection　of　98.5%,　NaCl　rejection　of　13.4%,　along　with　permeance　of　192.1　L　m−2　h−1·MPa−1.　In　addition,　the　membrane　showed　long-term　stability　and　good　acid　resistance.　©　2023　The　Authors