CO2　photoreduction　is　warmly　embraced　as　a　promising　strategy　to　attain　carbon　neutrality,　with　natural　photosynthesis　constituting　a　valuable　source　of　inspiration　for　catalyst　design.　Herein,　an　In2O3@ZIF-67　artificial　photosynthetic　nanoreactor　was　constructed　by　growing　ZIF-67　on　the　interior　and　exterior　of　MIL-68(In)-derived　hollow　In2O3　prisms　via　potential　nonclassical　crystallization　pathway(s),　forming　an　efficient　double　heterostructure　with　separated　reaction　centers　and　prompt　electron　transfers.　With　the　introduction　of　[Ru(bpy)3]2+　photosensitizer,　the　nanoreactor　possesses　two　antennae　to　harvest　visible　light.　Additionally,　the　macroscopic　architecture　permits　enhanced　light　and　photosensitizer　utilization,　while　ZIF-67　facilitates　the　capture　of　CO2.　Collectively,　the　developed　nanoreactor　exhibits　a　remarkable　CO　production　rate　of　33420　µmol　g−1h−1　with　the　diminished　quantity　of　the　photosensitizer.　Moreover,　the　hydrophobicity　of　the　nanoreactor　is　found　to　suppress　the　side　product　of　H2　and　elevate　CO　selectivity　to　94%,　further　demonstrating　the　superiority　of　its　exquisite　design.　©　2023　Elsevier　B.V.