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Author:

Zhang, Wenxiu (Zhang, Wenxiu.) | Duan, Ying (Duan, Ying.) | Qi, Lei (Qi, Lei.) | Li, Zhimei (Li, Zhimei.) | Ren, Jiechuan (Ren, Jiechuan.) | Nangale, Naluyele (Nangale, Naluyele.) | Yang, Chunlan (Yang, Chunlan.)

Indexed by:

Scopus SCIE

Abstract:

Temporal Lobe Epilepsy (TLE) is the most common subtype of focal epilepsy and the most refractory to drug treatment. Roughly 30% of patients do not have easily identifiable structural abnormalities. In other words, MRI-negative TLE has normal MRI scans on visual inspection. Thus, MRI-negative TLE is a diagnostic and therapeutic challenge. In this study, we investigate the cortical morphological brain network to identify MRI-negative TLE. The 210 cortical ROIs based on the Brainnetome atlas were used to define the network nodes. The least absolute shrinkage and selection operator (LASSO) algorithm and Pearson correlation methods were used to calculate the inter-regional morphometric features vector correlation respectively. As a result, two types of networks were constructed. The topological characteristics of networks were calculated by graph theory. Then after, a two-stage feature selection strategy, including a two-sample t-test and support vector machine-based recursive feature elimination (SVM-RFE), was performed in feature selection. Finally, classification with support vector machine (SVM) and leave-one-out cross-validation (LOOCV) was employed for the training and evaluation of the classifiers. The performance of two constructed brain networks was compared in MRI-negative TLE classification. The results indicated that the LASSO algorithm achieved better performance than the Pearson pairwise correlation method. The LASSO algorithm provides a robust method of individual morphological network construction for distinguishing patients with MRI-negative TLE from normal controls.

Keyword:

LASSO algorithm SVM Individual morphological brain network Pearson correlation

Author Community:

  • [ 1 ] [Zhang, Wenxiu]Beijing Univ Technol, Dept Environm & Life Sci, Beijing, Peoples R China
  • [ 2 ] [Yang, Chunlan]Beijing Univ Technol, Dept Environm & Life Sci, Beijing, Peoples R China
  • [ 3 ] [Duan, Ying]Beijing Universal Med Imaging Diagnost Ctr, Beijing, Peoples R China
  • [ 4 ] [Qi, Lei]Beijing Universal Med Imaging Diagnost Ctr, Beijing, Peoples R China
  • [ 5 ] [Li, Zhimei]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China
  • [ 6 ] [Ren, Jiechuan]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China
  • [ 7 ] [Nangale, Naluyele]Sterelin Med & Diagnost, Lusaka, Zambia

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Source :

BRAIN TOPOGRAPHY

ISSN: 0896-0267

Year: 2023

Issue: 4

Volume: 36

Page: 554-565

2 . 7 0 0

JCR@2022

ESI Discipline: NEUROSCIENCE & BEHAVIOR;

ESI HC Threshold:13

Cited Count:

WoS CC Cited Count: 1

SCOPUS Cited Count: 1

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 10

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