In　this　study,　persulphate　and　nanoscale　zero-valent　iron　were　activated　by　ultraviolet　irradiation　(PS/nZVI/UV),　followed　by　formation　of　dynamic　flocs　with　AlCl3-TiCl4　coagulant　directly　injected　into　a　gravity-driven　membrane　(GDM)　tank.　Membrane　fouling　caused　by　typical　organic　matter　fractions　including　humic　acid　(HA),　HA　together　with　bovine　serum　albumin　(HA-BSA),　HA　combined　with　polysaccharide　(HA-SA)　and　the　HA-BSA-SA　mixture　at　pH　of　6.0,　7.5　and　9.0　were　evaluated　by　specific　flux　and　fouling　resistance　distribution.　The　results　showed　that　GDM　pre-layered　with　AlCl3-TiCl4　flocs　exhibited　the　maximum　specific　flux,　followed　by　AlCl3　and　TiCl4.　Pre-oxidation　with　0.5　mM　PS　and　0.1　g　nZVI　under　UV　radiation　for　20　min　was　beneficial　to　degrade　HA　and　SA　fraction　with　molecular　weight　＞100　kDa　and　＜30　kDa,　and　BSA　fraction　with　＜30　kDa.　The　presence　of　BSA　attributed　mostly　to　irreversible　fouling,　SA　together　with　BAS　could　exacerbate　irreversible　fouling,　while　HA　caused　the　least　fouling.　The　irreversible　resistance　of　a　PS/nZVI/UV-GDM　system　was　62.79%,　27.27%,　58.03%　and　49.68%　lower　than　that　of　control　GDM　in　the　treatment　of　HA,　HA-BSA,　HA-SA　and　HA-BSA-SA,　respectively.　The　PS/nZVI/UV-GDM　system　could　achieve　the　highest　foulants　removal　efficiency　at　pH　of　6.0.　Morphological　observations　confirmed　the　differences　in　biofouling　layers　in　different　water　types.　Over　30-day　operation,　the　bacterial　genera　on　the　biofouling　layer　could　affect　the　organic　removals,　while　the　type　of　organic　matter　that　was　present　influenced　the　relative　abundance　of　bacterial　genera.