Alkaloids　are　a　material　treasure　bestowed　on　humans　by　nature　owing　to　their　numerous　biological　activities.　Orychophragine　D,　an　alkaloid　isolated　from　the　seeds　of　Orychophragmus　violaceus　was　identified　as　bearing　a　novel　skeleton　and　proved　to　have　an　excellent　radioprotective　effect.　Different　from　the　common　alkaloid　structure,　the　main　block　of　orychophragine　D　is　constructed　of　an　oxotriazine　and　an　oxopiperazine,　which　are　connected　in　parallel　by　a　C-N　bond.　In　this　paper,　a　preparation　method　for　the　novel　heterocycle　skeleton　of　orychophragine　D　is　proposed　for　the　first　time.　N-Boc-L-serine　was　utilized　as　the　original　material　to　complete　the　preparation　with　11　steps　in　a　13%　overall　yield.　A　hydroxyl　group　was　established　on　the　side　chain　of　the　skeleton　as　the　reaction　site　for　researchers　to　conduct　further　structural　modification　or　derivatization.