Buried　pipelines　are　susceptible　to　non-uniform　excitations　in　different　directions,　which　may　lead　to　severe　damage.　This　study　investigates　the　pipeline　performance　under　longitudinal　and　transverse　non-uniform　excitations　via　multi-point　shaking　table　tests.　The　results　demonstrated　that　the　seismic　response　of　pipeline　was　affected　more　by　soil　inconsistent　motion　under　transverse　non-uniform　excitations,　while　it　was　affected　more　by　the　degree　of　pipeline–soil　interaction　in　longitudinal　direction.　The　pipeline　maximum　peak　bending　strains　were　larger　than　the　maximum　peak　axial　strains　at　higher　loading　intensity.　These　indicated　that　the　pipeline　response　mechanisms　are　different　under　longitudinal　and　transverse　non-uniform　excitations.　©　2023　Taylor　&　Francis　Group,　LLC.