To　dissipate　a　large　amount　of　blast　energy　as　well　as　realize　a　reasonable　load　transfer　to　the　beam　and　column　instead　of　the　vulnerable　wall　in　the　frame　structure,　this　study　employs　a　novel　double-layered　system　to　protect　the　infilled　vulnerable　masonry　wall　to　resist　blast　loads.　The　system　comprises　a　sacrificial　cladding　directly　exposed　to　the　blast　to　dissipate　energy　and　connectors　to　facilitate　load　transfer　and　mitigation.　Based　on　the　quasi-static　compressive　test　on　the　connector,　the　field　blast　test　on　the　sacrificial　cladding　and　frame　structure　with　an　infilled　masonry　wall,　their　respective　numerical　models　are　established　and　validated　with　ANSYS/LS-DYNA,　which　facilitates　the　model　establishment　of　the　frame　structure　protected　by　the　double-layered　system　subjected　to　blast　load.　The　numerical　results　indicate　that　the　system　effectively　mitigates　the　damage　to　the　masonry　wall　and　reduces　the　load　transferred　to　the　frame　compared　to　that　without　protection.　However,　large　bending　deformation　of　the　sacrificial　cladding　may　still　result　in　collision　damage　to　the　vulnerable　wall　which　makes　it　difficult　to　be　applied　in　engineering　practice.　To　improve　the　protective　performance　of　the　double-layered　system　and　reduce　the　possibility　of　the　occurrence　of　a　collision　between　the　sacrificial　cladding　and　the　wall,　several　measures,　including　connector　layout　optimization,　rear　plate　strengthening　with　stiffeners,　and　appropriate　connector　height　determination　have　been　proposed.　The　numerical　results　demonstrate　that　installing　connectors　at　four　edges,　adding　5　x　5　stiffeners　on　the　rear　surface　of　the　sacrificial　cladding,　and　appropriately　designing　the　height　of　the　connector　can　significantly　enhance　the　double-layered　system＇s　protective　performance,　which　has　practical　significance　in　protecting　vulnerable　masonry　wall　in　frame　structure　from　blast　loads.