Municipal　solid　waste　incineration　(MSWI)　technology　has　the　advantages　of　energy　recyclability,　in-situ　incineration,　fast　processing　speed　and　high　capacity　reduction　rate.　However,　its　inputs　have　characteristics　of　diversity　and　time-varying　due　to　differences　in　economic　development,　living　habit　and　natural　environment.　In　addition,　it　is　also　influenced　by　the　operating　difference,　equipment　maintenance　and　seasonal　alternation.　Thus,　it　is　difficult　to　maintain　MSWI　process　to　run　in　optimized　operating　conditions.　In　order　to　ensure　the　safety　and　optimization　of　this　process,　this　paper　uses　chemical　process　simulation　software　to　simulate　a　MSWI　process　based　on　a　grate　furnace.　First,　the　research　object　is　described.　Then,　the　simulation　strategy　and　parameter　settings　of　the　whole　incineration　process　are　given.　Then,　the　whole　process　is　simulated　and　analyzed.　The　simulation　results　show　that　the　O-2　concentration　in　the　G1　flue　gas　can　reach　up　to　15%,　which　meets　the　requirement　of　full　burnout　of　combustibles.　In　the　flue　gas　G3,　the　error　between　the　simulated　value　of　the　pollutant　and　the　actual　value　is　within　an　acceptable　range.　The　simulation　results　can　effectively　reflect　the　status　of　MSWI.　So,　it　provide　effective　support　for　constructing　an　incineration　mechanism　model　of　a　near-real　MSWI　process.