Introduction:　The　tumor　microenvironment　(TME)　is　crucial　for　the　development　of　head　and　neck　squamous　cell　carcinoma　(HNSCC).　However,　the　correlation　of　the　characteristics　of　the　TME　and　the　prognosis　of　patients　with　HNSCC　remains　less　known.Methods:　In　this　study,　we　calculated　the　immune　and　stromal　cell　scores　using　the　＂estimate＂　R　package.　Kaplan-Meier　survival　and　CIBERSORT　algorithm　analyses　were　applied　in　this　study.Results:　We　identified　seven　new　markers:　FCGR3B,　IGHV3-64,　AC023449.2,　IGKV1D-8,　FCGR2A,　WDFY4,　and　HBQ1.　Subsequently,　a　risk　model　was　constructed　and　all　HNSCC　samples　were　grouped　into　low-　and　high-risk　groups.　The　results　of　both　the　Kaplan-Meier　survival　and　receiver　operating　characteristic　curve　(ROC)　analyses　showed　that　the　prognosis　indicated　by　the　model　was　accurate　(0.758,　0.756,　and　0.666　for　1-,　3-　and　5-year　survival　rates).　In　addition,　we　applied　the　CIBERSORT　algorithm　to　reveal　the　significant　differences　in　the　infiltration　levels　of　immune　cells　between　the　two　risk　groups.Discussion:　Our　study　elucidated　the　roles　of　the　TME　and　identified　new　prognostic　biomarkers　for　patients　with　HNSCC.