Connections　between　precast　bridge　deck　panels　(PBDPs)　have　the　risks　of　cracking　and　leaking　during　service　life,　influencing　the　performance　and　durability　of　PBDPs.　High-performance　materials　offer　the　possibility　for　simplifying　joint　configurations　and　increasing　serviceability　performance.　Traffic　causes　the　bridge　deck　panels　to　bear　the　action　of　fatigue　load　inevitably.　Therefore,　this　paper　conducted　validation　tests　and　fatigue　bending　tests　to　investigate　the　fatigue　behaviors　of　PBDPs　with　the　proposed　high-performance　connections.　Ultrahigh-performance　concrete　and　carbon　fiber-reinforced　polymer　tendons　were　adopted　in　the　proposed　connection.　The　validation　tests　proved　the　reliability　of　connections　in　the　longitudinal　and　transverse　directions　under　Vehicle　mode-III　in　the　Chinese　code.　The　fatigue　bending　tests　analyzed　the　performance　parameter　development　of　PBDPs　with　the　proposed　connection　during　the　whole　fatigue　process,　including　crack　pattern,　deflection,　strain,　stiffness,　and　energy　dissipation.　Then,　empirical　models　used　to　predict　fatigue　deflection　and　fatigue　damage　quantity　were　put　forward　based　on　the　test　results.　The　results　show　that　the　capacity　of　the　static　test　after　fatigue　is　2.17　and　13.63　times　the　upper　fatigue　limit　when　the　connection　is　along　the　support　direction　and　perpendicular　to　the　support　direction,　respectively.　The　proposed　high-performance　connection　has　enough　safe　reserves　irrespective　of　which　direction　it　is　arranged.　The　fatigue　damage　of　PBDPs　with　the　proposed　connection　under　moment　develops　in　three　stages:　rapid　development　of　fatigue　damage　stage,　stable　accumulation　of　damage　stage,　and　imminent　failure　stage.　The　maximum　midspan　deflection　and　logarithmic　cycle　numbers　present　linear　relationships.　These　empirical　models　have　ideal　accuracy　for　predicting　flexural　fatigue　deflection　and　accumulative　damage.　©　2023　American　Society　of　Civil　Engineers.