The　high　cost　of　laser　powder　bed　fusion　(LPBF)　fabricated　high-strength　Sc　containing　aluminium　alloy　hinders　its　applications.　To　reduce　the　cost,　we　reported　a　LPBF　fabricated　strong　and　ductile　Al–Mn–Mg–Sc–Zr　alloy　using　large　layer　thicknesses　to　improve　the　fabrication　efficiency　on　coarse　powder　particles.　A　high　relative　density　exceeding　99.2%　was　achieved　at　layer　thicknesses　up　to　120　μm.　In　post-process　heat-treated　specimens,　the　yield　strength　only　had　a　slight　6%　decrease　from　layer　thickness　of　30　to　120　μm;　such　a　decrease　in　strength　was　attributed　to　the　larger　grain　size　resulted　from　the　adopted　larger　layer　thickness.　The　fabricated　sample　at　layer　thickness　of　120　μm　still　exhibited　high　tensile　yield　strength　of　472　MPa　and　fracture　strain　of　∼10%.　This　work　showed　a　successful　application　of　improving　the　LPBF　fabrication　efficiency　of　high-strength　Al–Mn–Mg–Sc–Zr　alloy　using　large　layer　thickness　in　LPBF　process.　©　2023　The　Author(s).　Published　by　Informa　UK　Limited,　trading　as　Taylor　&　Francis　Group.