Combining　with　the　constitutive　relation　of　orthotropic　materials,　a　fatigue　topology　optimization　model　considering　orthotropic　materials　is　established　based　on　the　Independent　Continuous　Mapping　(ICM)　method.　It　uses　the　minimum　structural　mass　as　the　optimization　objective,　the　element　fatigue　life　as　the　constraint　condition,　and　the　criterion　method.　The　fatigue　life　filtration　function,　mass　filtration　function,　and　stiffness　filtration　function　are　introduced　to　identify　whether　the　material　is　retained.　The　effectuality　of　the　method　is　verified　by　several　numerical　examples,　and　the　influence　of　different　filter　function　coefficients　on　the　results　is　explored.　This　paper　has　some　theoretical　significance　for　considering　the　fatigue　properties　of　orthotropic　material　components　in　the　conceptual　design　stage.　©　Published　under　licence　by　IOP　Publishing　Ltd.