This　study　deals　with　the　state　observer　design　for　a　class　of　linear　time-delay　distributed　parameter　systems　(DPSs)　modeled　by　a　parabolic　partial　differential　equation　(PDE)　via　mobile　sensors.　Initially,　under　the　assumption　that　the　spatial　domain　is　decomposed　into　multiple　subdomains　according　to　the　number　of　mobile　sensors,　the　estimation　scheme　including　a　state　observer　and　the　guidance　of　mobile　sensors　is　proposed　for　the　linear　time-delay　DPS.　Then,　by　using　Lyapunov　direct　technique　and　the　projection　modification　algorithm,　a　design　of　the　state　observer　plus　mobile　sensor　guidance　laws　is　developed,　such　that　the　resulting　state　estimation　error　system　is　exponentially　stable　and　the　mobile　sensor　guidance　can　improve　the　transient　response　of　state　estimation　error.　Finally,　numerical　simulations　are　presented　to　show　the　effectiveness　of　the　proposed　method.