Two　centrifuge　shaking　table　tests　were　carried　out　to　investigate　the　seismic　response　of　a　subway　station　structure　in　liquefiable　interlayer　site.　For　the　centrifuge　shaking　table　test　of　underground　structures,　there　is　no　precedent　for　the　model　preparation　of　the　liquefiable　interlayer　site　for　reference.　In　the　paper,　some　model　making　techniques　were　proposed　for　the　liquefiable　interlayer　site,　including　the　preparation　of　liquefiable　interlayer　site　(clay　consolidation,　sand　saturation　and　assembly　of　interlayer　site),　structural　waterproof　treatment,　releasing　initial　pore　pressure　in　the　sand　layer　during　centrifugal　loading.　The　model　tests　obtained　ideal　results,　which　achieved　the　experimental　goal　of　studying　the　seismic　response　of　subway　station　structure　in　liquefiable　interlayer　site.　The　research　conclusions　are　as　follows.　The　vertical　inertia　effect　of　the　overlying　soil　could　significantly　increase　the　axial　pressure　on　the　columns　of　an　underground　frame　structure　and　then,　reduce　its　horizontal　deformation　capacity.　The　columns　are　the　weak　components　of　a　subway　station　structure,　which　are　easy　to　be　damaged　under　earthquake.　The　ends　of　a　column　are　the　vulnerable　parts　and　were　prone　to　damage.　The　classification　standard　of　the　limits　of　relative　displacement　ratio　for　underground　structure　proposed　by　Du　et　al.　(Du　et　al.　in　Earthq　Eng　Struct　Dyn　50:655-672,　2021)　is　reliable　and　can　provide　a　method　for　earthquake　damage　response　evaluation　of　an　underground　structure.