The　combination　of　organic　molecular　materials　and　inorganic　solid　materials　has　drawn　much　attention　in　various　scientific　research　fields，such　as　condensed　matter　physics，materials　engineering　technology，and　molecular　biology.　Organic　molecular　materials　have　their　own　unique　advantages，such　as　flexibility，plasticity，tunability，scalability，and　addressability.　Furthermore，they　can　easily　combine　with　inorganic　materials　to　form　heterojunctions　and　produce　unique　properties　at　the　interface.　Spintronics　has　brought　traditional　electronics　into　the　quantum　age.　In　the　field　of　information　storage　and　quantum　computing，the　investigation　about　manipulating　electron　spins　is　developing　rapidly.　Since　the　required　energy　to　manipulate　the　spin　of　an　electron　is　only　one-thousandth　of　the　energy　to　drive　the　directional　movement　of　an　electron，the　consumed　energy　of　spintronic　devices　is　much　lower　than　that　of　traditional　microelectronic　devices.　Spintronics　and　molecular　chemistry　have　achieved　extraordinary　research　results　in　their　respective　fields.　Their　combination　can　apply　the　advantages　of　molecular　diversity　to　manipulate　or　intervene　the　electron　spin.　New　functional　devices　with　molecular　interfaces　are　fabricated　based　on　this　research　direction，which　have　become　a　scientific　hotspot　in　the　information　storage　field.　Generally，spin　polarization　comes　from　magnetic　materials　controlled　by　magnetic　fields.　In　contrast，recent　studies　have　found　that　non-magnetic　chiral　molecules　can　produce　spin　polarization　through　their　chiral　structure.　This　phenomenon　is　called　chiral-induced　spin　selectivity（CISS）effect.　The　spiral　structure　of　chiral　molecules，such　as　DNA　and　peptides，can　induce　extremely　strong　spin-orbit　coupling，which　results　in　high　spin　polarization　in　electric　currents.　This　effect　has　been　confirmed　by　numerous　experiments.　The　discovery　of　the　CISS　effect　has　greatly　promoted　the　development　and　performance　of　spintronic　devices.　It　has　been　found　that　many　types　of　chiral　materials　have　the　CISS　effect　except　for　DNA　and　peptide　molecules，such　as　spiral　hydrocarbon　macromolecules，paramagnetic　chiral　molecules，superhelical　polyaniline　microfibers，and　chiral　hybrid　perovskites.　This　review　introduced　the　experimental　results，theoretical　models，device　performance，and　the　latest　research　progress　of　CISS　in　recent　years.　Compared　with　traditional　ferromagnetic　metals，the　CISS　effect　based　on　the　molecular　chiral　structure　had　many　advantages，such　as　high　spin　polarization，excellent　molecular　interface，simple　preparation　process，and　very　low　production　cost.　More　important，it　could　achieve　highly　efficient　spin　injection　into　metals　and　semiconductors　without　using　external　magnetic　fields　and　ferromagnetic　electrodes.　The　＂chiral　molecule/semiconductor＂　structure　was　reported　to　overcome　the　problem　of　interfacial　conductivity　mismatch.　A　smooth　charge/spin　transport　channel　was　formed　between　the　organic　molecule　and　the　semiconductor，which　greatly　reduced　charge/spin　scattering.　The　conductivity　phase　transition　from　metal　to　insulator　was　induced，and　a　large　modulation　of　Curie　temperature　and　magnetic　moment　orientation　was　obtained　in　semiconductors　through　molecules.　It　was　expected　to　achieve　highly　efficient　spin　injection　into　metals/semiconductors　through　self-assembling　chiral　molecules，instead　of　the　complex　process　of　growing　and　fabricating　ferromagnetic　metals.　Spin　logic　devices　with　ultra-high　speed，low　power　consumption　and　simple　preparation　were　designed.　This　review　introduced　the　novel　technologies　for　information　storage　by　using　non-magnetic　organic　molecules，which　provided　a　feasible　direction　for　the　practical　application　of　spintronic　devices.　©　2023　Editorial　Office　of　Chinese　Journal　of　Rare　Metals.　All　rights　reserved.