Given　the　importance　of　Ca2+　spark　and　Ca2+　nanospark　and　the　lack　of　relevant　simulation,　the　numerical　model　of　Ca2+　nanospark　is　constructed　in　this　paper.　We　constructed　a　kinetic　model　according　to　the　physiological　mechanism　of　Ca2+　nanospark　and　Ca2+　spark.　Then,　a　geometric　model　is　constructed　for　the　occurrence　space　of　Ca2+　nanospark　and　Ca2+　nanospark　and　a　structured　grid　for　it　is　generated.　Finally,　the　numerical　model　of　Ca2+　nanospark　is　constructed　by　using　the　finite　difference　method.　We　use　the　model　to　simulate　the　basic　Ca2+　spark　and　Ca2+　nanospark,　and　the　coincidence　degrees　of　most　temporal　properties　are　about　90%.　In　addition,　the　numerical　model　can　explore　the　corresponding　kinetics　changes　of　Ca2+　spark　and　Ca2+　nanospark　by　adjusting　the　model　parameters.　©　2023　SPIE.