In　order　to　obtain　the　response　spectrum　for　the　specific　nuclear　power　plant　(NPP),　considering　the　specific　site　condition　and　ground　motion　parameters,　the　stochastic　simulation　and　probabilistic　hazard　analysis　is　combined　to　obtain　the　UHS　which　the　probability　of　exceedance　is　10-4.　In　order　to　verify　the　seismic　performance　and　applicability　of　the　spectrum　in　the　actual　structure,　1:20　NPP　model　is　designed　for　shaking　table　test,　comparing　the　structure　response　of　two　natural　waves　and　two　artificial　waves　which　are　generated　by　the　safety　evaluation　spectrum　and　RG1.60　spectrum.　The　result　shows　that　different　wave　has　a　different　seismic　isolation　effect.　The　artificial　wave　generated　by　the　UHS　has　a　great　effect　on　the　acceleration　amplification　and　the　displacement　of　the　NPP.　The　floor　response　spectrum　amplitude　which　caused　by　UHS　is　higher　than　other　waves.　It　should　be　considered　in　the　structure　and　equipment　seismic　design.　©　2018,　Editorial　Board　of　Journal　of　Nuclear　Power　Engineering.　All　right　reserved.