• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
搜索

Author:

Yang, Yao (Yang, Yao.) | Wang, Junjie (Wang, Junjie.) | Qiao, Aike (Qiao, Aike.) (Scholars:乔爱科) | Fan, Xiangming (Fan, Xiangming.)

Indexed by:

Scopus SCIE PubMed

Abstract:

Objective The geometric configuration of the intraventricular tunnel is related to the re-intervention of left ventricular outflow tract stenosis after double outlet right ventricle (DORV) correction. Hemodynamic simulation was performed in order to study the influence of the geometric configuration of the IVT on the pressure difference. Methods CT images of DORV were processed to reconstruct 3D models of left and right ventricular flow chambers and aortic valve orifice, and then the size and relative position of the aortic valve orifice and ventricular septal defect were determined. Twenty five groups of the idealized models were established according to orthogonal test design and computational fluid dynamics method was applied to simulate hemodynamics. Three factors of geometric configuration were considered for the study of their influences on the pressure difference. The first factor is the distance between the ventricular septal defect and the plane of the aortic valve (D-SA), the second factor is the ejection angle of blood from left ventricle flowing into the IVT (A(LT)), and the third factor is the turning radius of the IVT (R-TT). SPSS software was employed to perform the orthogonal analysis. Additionally, twelve models with different turning radii were established for hemodynamic analysis, with the turning radii increasing from 0 mm with an interval of 1 mm, so as to study the influence of turning radius on pressure difference of IVT. Results The analysis of variance showed that only the change of R-TT had a significant effect on the pressure difference (P = 0 < 0.05), while the change of D-SA and A(LT) had no significant effect on the pressure difference (P = 0.459 > 0.05, P = 0.263 > 0.05). The pressure difference decreases with the increase of R-TT. When R-TT reaches 6 mm, the pressure difference gradually remains unchanged with the increase of R-TT, and the rate of change is less than 5%. Conclusion R-TT in the IVT is the main factor affecting the pressure difference. A small R-TT will lead to a large pressure difference in the IVT. When R-TT increases to 6 mm, the pressure difference in the IVT remains nearly unchanged. When performing the right ventricular double outlet correction; the turning radius of the IVT should be about 6 mm to ensure relatively small pressure difference.

Keyword:

numerical simulation double outlet right ventricle surgical planning intraventricular tunnel hemodynamics

Author Community:

  • [ 1 ] [Yang, Yao]Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China
  • [ 2 ] [Wang, Junjie]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
  • [ 3 ] [Qiao, Aike]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
  • [ 4 ] [Fan, Xiangming]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China

Reprint Author's Address:

  • [Fan, Xiangming]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China

Show more details

Related Keywords:

Source :

FRONTIERS IN PHYSIOLOGY

ISSN: 1664-042X

Year: 2020

Volume: 11

4 . 0 0 0

JCR@2022

ESI Discipline: BIOLOGY & BIOCHEMISTRY;

ESI HC Threshold:136

Cited Count:

WoS CC Cited Count: 7

SCOPUS Cited Count: 7

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 10

Online/Total:529/10713517
Address:BJUT Library(100 Pingleyuan,Chaoyang District,Beijing 100124, China Post Code:100124) Contact Us:010-67392185
Copyright:BJUT Library Technical Support:Beijing Aegean Software Co., Ltd.