This　study　investigates　the　anisotropy　effect　of　Ta10W　alloy　manufactured　by　selective　laser　melting　(SLM)　on　the　microstructure　and　mechanical　properties　of　the　three　butt　welds.　The　welds　were　characterized　by　formation,　microstructure,　microhardness,　room　temperature　(RT)　strength,　high　temperature　(HT)　strength,　and　fracture　morphology.　Re-sults　indicate　that　Ta10W　manufactured　by　SLM　exhibits　anisotropy　in　microstructure　and　properties,　leading　to　notable　differences　in　the　welds＇　microstructure　and　mechanical　properties.　When　the　base　metal＇s　X-axis　aligns　with　the　welding　direction,　the　weld　forms　columnar　sub-grains,　whereas　aligning　the　base　metal＇s　Z-axis　with　the　welding　direction　results　in　equiaxed　sub-grains　in　the　weld.　These　distinct　microstructures　influence　the　maximum　RT　strength,　with　the　X　+　X　weld　displaying　significantly　higher　strength　(751.33　MPa)　compared　to　the　X　+　Z　(672.00　MPa)　and　Z　+　Z　(667.25　MPa)　welds.　Fracture　analysis　reveals　a　transition　from　cleavage　fracture　to　intergranular　fracture　in　three　welds.　The　microhardness　and　HT　strength　of　the　welds　exhibit　an　inapparent　difference,　with　the　microhardness　of　approximately　305　HV0.2/15　and　the　HT　(1800　degrees　C)　strength　of　around　110.50　MPa.(c)　2023　The　Authors.　Published　by　Elsevier　B.V.　This　is　an　open　access　article　under　the　CC　BY-NC-ND　license　(http://creativecommons.org/licenses/by-nc-nd/4.0/).