For　the　cross　domain　scheduling　problem　of　time-sensitive　network,　a　software-defined　cross-domain　scheduling　me-chanism　for　time-sensitive　networking　was　proposed,　which　was　based　on　three　kinds　of　wide　area　clock　synchronization　technology　to　ensure　nanosecond　inter-domain　time　synchronization.　Then,　a　time　slot　conflict-free　cross　domain　scheduling　model　was　proposed　to　solve　the　problem　of　time　slot　alignment　caused　by　inter-domain　link　delay.　The　time　slot　conflict-free　constraints　were　used　to　strictly　limit　the　arrival　time　of　cross-domain　traffic　at　the　edge　node.　Finally,　the　gate　control　list　of　fusion　domains　for　global　scheduling　was　calculated　online.　The　simulation　results　show　that　the　model　can　schedule　hundreds　of　time-sensitive　traffic　in　a　typical　cross-domain　remote　control　scenario,　and　has　a　feasible　algorithm　execution　time　in　seconds.　©　2021,　Editorial　Board　of　Journal　on　Communications.　All　right　reserved.