The　real-time　dynamic　substructure　tests　of　the　shaking　table　are　performed,　including　four　structural　systems:　regular　steel　moment-resisting　frame　(R-SMRF),　irregular　steel　moment-resisting　frame　(Ir-SMRF),　regular　steel　moment-resisting　frame　considering　soil　structure　interaction　(R-SMRF-SSI),　and　irregular　steel　moment-resisting　frame　considering　soil　structure　interaction　(Ir-SMRF-SSI).The　influence　of　mass　irregularity　and　soil-structure　interaction　on　the　seismic　collapse　resistance　of　low-rise　steel　frame　structure　is　evaluated.　It　is　noted　that　whiplash　effect　leads　to　increase　of　acceleration　response　of　the　top　story　in　minor　earthquake.　In　contrast,　medium　earthquake　cause　structural　damage,　so　the　equipped-mass　reduces　the　acceleration　response.　The　foundation　significantly　reduces　acceleration　response　of　structure　because　the　natural　period　of　structure　system　increases.　As　the　seismic　intensity　increases,　displacement　response　of　structure　increases.　Damage　and　residual　deformation　of　structure　occurs　during　medium　earthquake,　and　structure　eventually　collapses　due　to　lateral　displacement　of　the　first　storey　in　the　rare　earthquake.　The　foundation　has　a　damping　effect,　but　the　equipped-mass　is　not　conducive　to　for　the　seismic　resistance　of　the　structure.　©　2020,　Editorial　Office　of　China　Civil　Engineering　Journal.　All　right　reserved.