The　vibration　of　Cross-Laminated　Timber　(CLT)　floor　is　closely　related　to　the　human-induced　load.　However,　at　present,　the　research　on　human-induced　vibration　of　CLT　floor　is　mostly　limited　to　single　person　activity.　In　this　study,　the　influence　of　multi-person　load　on　the　dynamic　performance　of　CLT　floor　was　studied.　The　open　source　software　framework　seismic　engineering　simulation　open　software　(OPEN-SEES)　was　used　to　simulate　the　dynamic　performance　of　CLT　floor.　A　new　model　was　developed　to　simulate　the　behavior　of　structures,　and　perform　walking/running　load　analysis　for　CLT　floor.　The　simulation　results　agree　well　with　the　experimental　data.　The　simulation　results　show　that　increasing　the　number　of　pedestrians　will　significantly　increase　the　vibration　response　of　CLT　floor　and　adversely　affect　the　comfort　evaluation　of　occupants.　©　2021　Taylor　&　Francis　Group,　London.