In　the　grassland　highway　environment,　monotonous　landscape　is　likely　to　cause　drivers　driving　fatigue,　which　leads　to　the　occurrence　of　traffic　accidents.　For　this　reason,　the　application　of　driving　fatigue　prevention　safety　facilities　is　particularly　important.　In　this　paper　a　kind　of　colored　road　pavement　fatigue　prevention　safety　facility　was　mentioned.　Studies　have　shown　that　driving　fatigue　is　easy　to　cause　changes　in　drivers＇　driving　behavior　and　alertness.　In　this　paper,　a　driving　simulation　experiment　was　conducted,　based　on　the　analysis　of　driver＇s　driving　behavior,　KSS　value　and　reaction　time,　significance　analysis　were　used　to　analyze　the　effectiveness　of　the　fatigue　prevention　safety　facility.　The　result　showed　that　the　colored　road　pavement　fatigue　prevention　safety　facility　could　make　a　difference　on　drivers＇　driving　behavior　and　reduce　the　increase　of　drivers＇　feelings　of　fatigue　and　reaction　time.　The　experimental　results　could　provide　reference　for　the　application　of　fatigue　prevention　safety　facilities.　　©　2020　American　Society　of　Civil　Engineers.