An　installation　was　designed　to　link　prefabricated　external　wall　panels　and　steel　frame　together.　In　order　to　investigate　the　mechanical　behavior　and　the　seismic　behavior　of　steel　frame　structure　with　prefabricated　external　wall　panel　(wall-steel　frame),　wall-steel　frame　models　and　other　correlative　models　were　built　and　analyzed　under　monotonic　loading　and　cyclic　loading　by　software　ABAQUS.　The　results　show　that,　the　new　connection　has　sufficient　bearing　capacity　and　effective　connection.　The　connection　can　also　limit　the　forces　transmitted　though　the　panel　to　avoid　the　damage　in　the　panel　and　keep　the　wall　panel　elastic　to　work　with　frame　when　the　structure　deforms　largely　under　lateral　force;　the　cladding　system　consisting　of　the　prefabricated　connections　and　external　wall　panel　improves　118%　initial　stiffness　and　30%　ultimate　bearing　capacity　of　the　steel　frame;　The　installation　improves　the　seismic　behavior　of　wall-steel　frame.　When　the　structure　fails,　the　total　energy　dissipation　of　wall-steel　frame　improves　90%　compared　with　steel　frame　under　cyclic　loading.　©　2016,　Editorial　Office　of　Journal　of　Building　Structures.　All　right　reserved.