With　the　development　of　nanotechnology,　nanomaterials　with　controllable　structure,　multifunctional　surface　and　good　biocompatibility　have　been　widely　used　in　various　aspects　of　biomedicine.　As　an　important　blood　biomarker,　circulating　tumor　cells　(CTC)　are　the　＂seeds＂　of　tumor　metastasis.　With　the　flow　of　blood,　tumor　cells　with　strong　vitality　can　pass　through　blood　vessels　and　gather　at　the　distal　end　to　form　tiny　tumor　thrombi.　Therefore,　the　detection　of　CTC　can　be　used　for　early　diagnosis　of　cancer　and　assessment　of　metastasis.　The　application　of　new　nanomaterials　and　nanomaterial　characterization　measurement　technology　has　a　great　impact　on　the　progress　of　CTC　analysis　technology.　In　recent　years,　the　capture　and　detection　of　CTC　based　on　nanomaterials　and　microfluidic　technology　has　become　a　research　hotspot　in　liquid　biopsy,　and　this　technology　has　been　gradually　extended　to　clinical　applications.　This　article　reviews　the　role　of　nanomaterials　and　nanotechnology　in　the　capture　and　detection　of　CTC,　and　looks　forward　to　the　application　prospects　of　bioanalysis　in　this　field.　©　2021　Institute　of　Biophysics,Chinese　Academy　of　Sciences.　All　rights　reserved.