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Author:

Gao, Ruiyang (Gao, Ruiyang.) | Tsui, Po-Hsiang (Tsui, Po-Hsiang.) | Wu, Shuicai (Wu, Shuicai.) (Scholars:吴水才) | Tai, Dar-In (Tai, Dar-In.) | Bin, Guangyu (Bin, Guangyu.) | Zhou, Zhuhuang (Zhou, Zhuhuang.) | Loffroy, Romaric (Loffroy, Romaric.) | Bini, Fabiano (Bini, Fabiano.)

Indexed by:

Scopus SCIE

Abstract:

In this paper, we present the kernel density estimation (KDE)-based parallelized ultrasound entropy imaging and apply it for hepatic steatosis characterization. A KDE technique was used to estimate the probability density function (PDF) of ultrasound backscattered signals. The estimated PDF was utilized to estimate the Shannon entropy to construct parametric images. In addition, the parallel computation technique was incorporated. Clinical experiments of hepatic steatosis were conducted to validate the feasibility of the proposed method. Seventy-two participants and 204 patients with different grades of hepatic steatosis were included. The experimental results show that the KDE-based entropy parameter correlates with log(10) (hepatic fat fractions) measured by magnetic resonance spectroscopy in the 72 participants (Pearson's r = 0.52, p < 0.0001), and its areas under the receiver operating characteristic curves for diagnosing hepatic steatosis grades >= mild, >= moderate, and >= severe are 0.65, 0.73, and 0.80, respectively, for the 204 patients. The proposed method overcomes the drawbacks of conventional histogram-based ultrasound entropy imaging, including limited dynamic ranges and histogram settings dependence, although the diagnostic performance is slightly worse than conventional histogram-based entropy imaging. The proposed KDE-based parallelized ultrasound entropy imaging technique may be used as a new ultrasound entropy imaging method for hepatic steatosis characterization.

Keyword:

ultrasound entropy imaging probability density function quantitative ultrasound ultrasound backscattered signals backscatter envelope statistics kernel density estimation hepatic steatosis ultrasound tissue characterization

Author Community:

  • [ 1 ] [Gao, Ruiyang]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 2 ] [Wu, Shuicai]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 3 ] [Bin, Guangyu]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 4 ] [Zhou, Zhuhuang]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 5 ] [Tsui, Po-Hsiang]Chang Gung Univ, Coll Med, Dept Med Imaging & Radiol Sci, Taoyuan, Taiwan
  • [ 6 ] [Tsui, Po-Hsiang]Chang Gung Univ, Res Ctr Radiat Med, Taoyuan, Taiwan
  • [ 7 ] [Tsui, Po-Hsiang]Chang Gung Mem Hosp Linkou, Dept Pediat, Div Pediat Gastroenterol, Taoyuan, Taiwan
  • [ 8 ] [Tai, Dar-In]Chang Gung Univ, Chang Gung Mem Hosp Linkou, Dept Gastroenterol & Hepatol, Taoyuan, Taiwan

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Source :

DIAGNOSTICS

Year: 2023

Issue: 24

Volume: 13

3 . 6 0 0

JCR@2022

Cited Count:

WoS CC Cited Count: 2

SCOPUS Cited Count: 3

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 6

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