The　traditional　interlayer　shear　model　of　the　building　structure　is　not　consistent　with　the　real　stress　of　the　structure，and　cannot　accurately　reflect　the　dynamic　response　of　the　actual　multi-dimensional　eccentric　structure，so　the　engineering　feasibility　is　not　enough.　The　current　simplified　model　building　method　of　bending-shear　is　inefficient　and　cannot　directly　guide　the　modeling　of　three-dimensional　eccentric　structure.　According　to　the　basic　principle　of　flexibility　method　in　structural　mechanics，a　fast　and　accu‑　rate　method　for　establishing　interlayer　flexural　shear　model　is　proposed.　On　this　basis，considering　the　influence　of　the　structure＇s　eccentricity　on　the　dynamic　response　of　the　structure，a　three-dimensional　bending-shear　eccentricity　model　is　established，and　the　effectiveness　of　the　structural　damping　control　under　bidirectional　and　torsional　seismic　waves　is　verified　by　multi-dimensional　time-history　analysis.　The　results　show　that　the　simplified　three-dimensional　flexural　shear　eccentricity　model　based　on　the　flexibility　method　has　the　advantages　of　high　modeling　accuracy　and　computational　efficiency，and　can　accurately　reflect　the　dynamic　response　of　the　real　structure　under　multi-dimensional　earthquake　action.　The　optimal　arrangement　of　the　tuned　dampers　after　considering　the　actual　eccentricity　can　fully　exploit　the　damping　performance.　©　2023　Nanjing　University　of　Aeronautics　an　Astronautics.　All　rights　reserved.