When　an　underground　structure　crosses　the　liquefiable　soil　layer，the　site　liquefaction　may　have　an　adverse　effect　on　the　dynamic　response　of　the　structure.　A　two-dimensional　finite　element　model　of　the　soil-structure　dynamic　interaction　at　a　local　liquefiable　interlayer　site　was　established　using　centrifuge　shaking　table　test　platform.　The　calculation　model　accounts　the　significant　shear　deformation　of　sand　during　liquefaction，as　well　as　the　nonlinear　properties　of　the　interface　between　the　saturated　two-phase　medium　and　structure.　To　ensure　the　accuracy　of　the　numerical　model，the　numerical　results　are　compared　to　the　experimental　data.　In　addition，the　influence　of　soil-structure　interface　on　structural　seismic　response　was　analyzed.　The　results　show　that　the　increase　in　pore　pressure　is　due　to　the　cumulative　effect　of　seismic　action.　Due　to　soil　interactions，the　excess　pore　pressure　in　the　near-field　rises　faster　than　in　the　far-field，and　it　dissipates　faster　due　to　the　inconsistency　in　the　soil　and　structural　deformation.　For　local　liquefiable　interlayer　sites，binding　soil-structure　interface　will　amplify　the　seismic　response　of　the　structure.　The　larger　the　intensity　of　ground　motion，the　greater　the　liquefaction　of　the　saturated　sand　and　the　nonlinear　properties　of　the　site.　Furthermore，the　greater　the　difference　in　stiffness　of　soil　and　structure　and　the　bigger　the　inaccuracy　produced　by　the　binding　contact　of　the　soil　interface.　The　study　suggests　to　consider　the　nonlinear　problems　of　soil-structure　interface　for　local　liquefiable　interlayer　sites.　©　2023　Academia　Sinica.　All　rights　reserved.