This　work　presents　a　method　that　allows　continuous　blood　glucose　monitoring　and　provides　a　complete　circuit　that　can　continuously　process　a　larger　range　of　input　currents　for　the　more　sensitive　needle　electrodes　with　electrodeposition　technology.　The　circuit　uses　switched-capacitor　to　differentially　process　the　two　parts　of　the　signals　from　target　electrode　and　background　reference　electrode,　thus　greatly　reducing　the　interference　current　generated　by　the　complex　blood　environment　of　the　human　body.　This　work　also　makes　full　use　of　the　adjustable　characteristics　of　the　circuit　by　adjusting　the　frequency　of　sampling　and　capacitance　size　of　the　circuit　for　different　input　current　ranges,　which　maintains　the　excellent　performance　of　the　circuit.　The　monitor　and　readout　IC　proposed　in　this　paper　reduces　the　overall　power　consumption　to　0.98　mW　under　3.3　V　supply　voltage,　while　it　extends　the　input　current　range　to　more　than　48　μ　A　with　minimum　input-referred　noise　of　16　pArms.　©　2023　IEEE.