Multi-dimensional　multiplexed　metasurface　holography　extends　holographic　information　capacity　and　promises　revolutionary　advancements　for　vivid　imaging,　information　storage,　and　encryption.　However,　achieving　multifunctional　metasurface　holography　by　forward　design　method　is　still　difficult　because　it　relies　heavily　on　Jones　matrix　engineering,　which　places　high　demands　on　physical　knowledge　and　processing　technology.　To　break　these　limitations　and　simplify　the　design　process,　here,　an　end-to-end　inverse　design　framework　is　proposed.　By　directly　linking　the　metasurface　to　the　reconstructed　images　and　employing　a　loss　function　to　guide　the　update　of　metasurface,　the　calculation　of　hologram　can　be　omitted;　thus,　greatly　simplifying　the　design　process.　In　addition,　the　requirements　on　the　completeness　of　meta-library　can　also　be　significantly　reduced,　allowing　multi-channel　hologram　to　be　achieved　using　meta-atoms　with　only　two　degrees　of　freedom,　which　is　very　friendly　to　processing.　By　exploiting　the　proposed　method,　metasurface　hologram　containing　up　to　12　channels　of　multi-wavelength,　multi-plane,　and　multi-polarization　is　designed　and　experimentally　demonstrated,　which　exhibits　the　state-of-the-art　information　multiplexing　capacity　of　the　metasurface　composed　of　simple　meta-atoms.　This　method　is　conducive　to　promoting　the　intelligent　design　of　multifunctional　meta-devices,　and　it　is　expected　to　eventually　accelerate　the　application　of　meta-devices　in　colorful　display,　imaging,　storage　and　other　fields.　©　2024　Wiley-VCH　GmbH.