In　order　to　increase　the　scalability　and　reduce　the　complexity　of　photonic　multipath　SIC　systems,　a　photonic　multipath　self-interference　cancellation　(SIC)　method　based　on　optical　frequency　comb　(OFC)　is　proposed.　The　OFC　is　generated　by　continuously　frequency-shifting　the　seed　laser　in　the　re-circulating　frequency　shifter　(RFS)　loop.　The　reference　signal　is　modulated　to　the　multiple　combs　of　the　OFC　via　a　Mach-Zehnder　modulator　(MZM),　and　the　received　signal　is　loaded　into　another　MZM.　These　two　MZMs　work　at　opposite　quadrature　bias　points　to　reverse　the　phase　of　the　received　signal　and　the　reference　signal.　After　splitting　and　filtering　with　a　dense　wavelength　division　multiplexer,　the　reference　modulation　signals　are　injected　into　a　multipath　amplitude-delay　matched　link,　where　the　amplitude　and　delay　time　are　accurately　controlled　by　several　sets　of　optical　variable　attenuators　and　tunable　delay　lines.　Both　the　inversion　and　amplitude-delay　matching　of　the　reference　signals　are　realised　in　the　optical　domain,　contributing　to　a　broad　bandwidth　and　high　operational　frequency.　Experimental　results　show　that　the　cancellation　depth　is　greater　than　45.9　dB　for　single-frequency　signals,　and　23.9　dB　for　signals　with　a　bandwidth　of　100　MHz　in　a　setup　with　three　self-interference　paths.　The　proposed　method　is　characterized　by　easy　scalability,　good　flexibility,　and　low　cost,　making　it　suitable　for　complex　multipath　SIC　in　in-band　full-duplex　wireless　systems.