Hybrid　metal　halides　are　emerging　candidates　for　X-ray　imaging.　Due　to　the　poor　uniformity,　low　transmittance　and　high　light　scattering　of　polycrystalline　film　scintillator　screen,　resulting　in　low　resolution　of　X-ray　imaging,　it　is　essential　a　challenging　to　explore　new　large-area　and　single　crystal　scintillator　with　high　light　yield　and　high　resolution.　Herein,　inch-sized　Mn-based　halide　single　crystals,　(C25H22P)2MnCl4　and　(C25H22P)2MnBr4,　with　tunable　thickness　films　from　0.12　mm　to　0.72　mm　were　designed　and　grown.　The　crystals　of　(C25H22P)2MnCl4　and　(C25H22P)2MnBr4　with　high　photoluminescence　quantum　yield　(PLQY)　of　62.42　%　and　99.10　%　exhibit　high　light　yield　of　56,457　and　78,937　photons/MeV　under　X-ray,　which　is　1.7　and　2.37　times　higher　than　that　of　the　commercial　LYSO　scintillator.　Both　the　crystals　show　high　X-ray　radiation　resistance　even　exposed　to　X-ray　for　60　mins　with　a　high　dose　rate　of　504　mGy　s−1.　The　high　photochemical　stability　under　the　continuous　UV　and　X-ray　irradiation　contributes　them　towards　X‑ray　imaging.　With　such　significant　merits,　the　high　spatial　resolutions　about　21.02　and　25.61　lp/mm　are　achieved　on　the　(C25H22P)2MnCl4　and　(C25H22P)2MnBr4　single　crystal　films,　which　demonstrates　the　great　potential　of　large　size　single　crystal　screen　for　commercial　high-resolution　X-ray　imaging　applications.　©　2024　Elsevier　B.V.