The　present　study　focuses　on　the　development　of　a　novel　venturi-based　self-excited　oscillation　mixer　that　effectively　utilizes　the　venturi　effect　to　facilitate　efficient　abrasive　intake　while　simultaneously　ensuring　effective　prevention　of　backflow　through　the　utilization　of　the　systolic　section　within　the　venturi　tube.　It　not　only　ensures　uniform　mixing　of　water　and　abrasive　but　also　transforms　the　continuous　jet　into　a　pulsed　one,　thereby　significantly　enhancing　exit　velocity.　The　orthogonal　experimental　design　method　and　single　factor　experiment　method　were　employed　to　investigate　the　effects　of　inlet　water　pressure,　water　nozzle　diameter,　abrasive　inlet　angle,　aspect　ratio　of　the　self-excited　oscillation　mixer,　and　abrasive　pipe　inlet　diameter　on　the　inlet　pressure　of　the　abrasive　pipe　and　the　velocity　of　the　jet　exit　in　the　new　mixing　device.　Approximate　response　surface　models　for　these　parameters　were　constructed　using　lsight　optimization　software,　combining　the　results　of　orthogonal　experimental　simulation.　By　employing　a　multi-island　genetic　algorithm,　we　have　globally　optimized　this　innovative　mixing　device　to　determine　its　optimal　performance　parameters.　Subsequently,　comparative　experiments　were　conducted　to　validate　the　performance　of　different　mixing　devices　in　descaling　applications.　Through　experimental　verification,　it　was　found　that　the　venturi-self-excited　oscillation　mixer　exhibits　excellent　rust　removal　capabilities　in　steel　plate　tests　compared　to　traditional　self-excited　oscillation　mixers.　These　findings　provide　valuable　guidance　for　the　subsequent　design　and　enhancement　of　abrasive　water　jet　mixers.　©　2024　Author(s).