The　preparation　of　electrocatalysts　with　high　performance　for　the　ethanol　oxidation　reaction　is　vital　for　the　large-scale　commercialization　of　direct　ethanol　fuel　cells.　Here,　we　successfully　synthesized　a　high-performance　electrocatalyst　of　a　AuPd　alloy　with　a　decreased　alloying　degree　via　pulsed　laser　irradiation　in　liquids.　As　indicated　by　the　experimental　results,　the　photochemical　effect-induced　surficial　deposition　of　Pd　atoms,　combined　with　the　photothermal　effect-induced　interdiffusion　of　Au　and　Pd　atoms,　resulted　in　the　formation　of　AuPd　alloys　with　a　decreased　alloying　degree.　Structural　characterization　reveals　that　L-AuPd　exhibits　a　lower　degree　of　alloying　compared　to　C-AuPd　prepared　via　the　conventional　co-reduction　method.　This　distinct　structure　endows　L-AuPd　with　outstanding　catalytic　activity　and　stability　in　EOR,　achieving　mass　and　specific　activities　as　high　as　16.01　A　mgPd−1　and　20.69　mA　cm−2,　9.1　and　5.2　times　than　that　of　the　commercial　Pd/C　respectively.　Furthermore,　L-AuPd　retains　90.1%　of　its　initial　mass　activity　after　300　cycles.　This　work　offers　guidance　for　laser-assisted　fabrication　of　efficient　Pd-based　catalysts　in　EOR.　©　2024　by　the　authors.