Structured　light　refers　to　the　light　field　tailored　by　various　degrees　of　freedom　including　intensity,　phase,　and　polarization　states　in　both　spatial　and　temporal　domains,　which　may　greatly　vitalize　the　technologies　in　both　optics,　such　as　the　next-generation　optical　communication　as　well　as　subwavelength　imaging　and　the　materials　science　in　both　fabrication　and　characterization.　The　structured　characteristics　of　the　structure　light　need　materials　also　with　structured　optical　properties　that　can　generate　or　manipulate　structured　light　in　a　straightforward　way,　which　can　be　well　satisfied　by　liquid　crystals,　a　soft　mater　that　can　self-assemble　into　tunable　ordered　structures　through　external　stimuli.　This　review　summarizes　the　research　progress　of　the　liquid　crystal-based　devices　used　in　structured　light　generations　and　modulations,　including　the　well-established　techniques　in　the　market,　like　the　spatial　light　modulator,　q-plate　and　the　liquid　crystal　integrated　optical　metasurfaces.　Especially,　light-matter　interactions　are　discussed　from　the　topological　view　of　both　the　structured　light　and　the　liquid　crystal　structures.　Such　a　perfect　matching　in　topology　makes　the　liquid　crystal　a　promising　star　together　with　structured　light　in　future　optic　and　photonic　technologies.　©　2024　Wiley-VCH　GmbH.