Sleep　deficits　is　associated　with　impaired　cognitive　and　affective　processes,　including　responses　to　salient　stimuli.　Monetary　win　and　loss　are　both　salient.　We　examined　how　sleep　deficits　and　comorbid　negative　emotional　states　are　associated　with　neural　markers　of　win　and　loss　processing.　We　curated　the　Human　Connectome　Project　data　and　employed　connectome-based　predictive　model　(CPM)　to　investigate　how　functional　connectivity　(FC)　features　of　win　and　loss　processing　associated　with　sleep　deficits,　as　reflected　in　the　Pittsburgh　Sleep　Quality　Index　(PSQI)　score,　and　subjective　emotional　states　in　981　young　adults.　Imaging　data　were　processed　with　published　routines　and　evaluated　with　a　corrected　threshold.　We　examined　the　inter-relationship　amongst　win/loss　FC,　PSQI　score,　and　clinical　measures　with　mediation　and　path　analyses.　Poorer　sleep　quality　is　associated　with　higher　right　inferior　temporal　gyrus　connectivity　with　amygdala　(rITG-rAmyg)　and　lower　connectivity　with　cerebellum　(rITG-CBL)　during　monetary　loss　but　not　win.　Both　rITG　FCs　and　PSQI　score　were　significantly　correlated　with　perceived　stress.　Further,　mediation　and　path　analyses　showed　that　rITG-rAmyg　and　rITG-CBL　antagonistically　modulate　PSQI　to　regulate　perceived　stress.　Poorer　sleep　quality　was　associated　with　higher　rITG-rAmyg　and　lower　rITG-CBL　during　monetary　loss.　Notably,　altered　rITG-rAmyg　and　rITG-CBL　antagonistically　modulated　sleep　quality　via　their　opposing　influences　on　perceived　stress.　Thus,　rIGT　FCs　exhibit　functional　antagonism　such　that　the　rITG-rAmyg　connectivity　worse　sleep　quality　and　perceived　stress　whereas　the　rITG-CBL　serves　to　counter　that　effect.　©　2023　ACM.