Recently,　photocatalysis　combined　peroxydisulfate　activation　under　visible　light　(PC-PDS/Vis)　was　developed　as　a　promising　technology　for　removing　antibiotics　in　water.　Herein,　Mn　doped　FeOOH　(Mn-FeOOH)　nanoclusters　were　grown　in-situ　on　the　surface　of　graphitic　carbon　nitride　nanosheets　(CNNS)　using　a　wet　chemical　method,　which　served　as　a　visible-light-driven　photocatalyst　for　peroxydisulfate　(PDS)　activation.　Photovoltaic　property　characterizations　revealed　that　Mn-FeOOH/CNNS　owned　superior　light　capture　ability　and　carrier　separation　efficiency.　According　to　DFT　calculations,　the　synergistic　effect　between　Mn　and　Fe　species　was　proved　to　enhance　the　adsorption　and　activation　of　PDS.　99.7%　of　tetracycline　(TC)　was　rapidly　removed　in　50　min　in　the　PC-PDS/Vis　system.　In　addition,　Mn-FeOOH/CNNS　exhibited　high　recycling　stability　with　low　iron　leaching,　attributed　to　the　interaction　between　Mn-FeOOH　clusters　and　carbon　species.　Quenching　experiments　and　electron　spin　resonance　(ESR)　tests　unveiled　that　O-center　dot(2)-　played　a　significant　role　in　TC　removal,　while　(OH)-O-center　dot　and　SO4　center　dot-　acted　as　additional　roles　contributing　to　the　overall　process.　These　findings　given　a　new　strategy　for　antibiotics　degradation　by　photocatalysis,　offering　deeper　insights　for　the　advancement　of　sustainable　and　cutting-edge　wastewater　treatment　technologies.