Chloroquine　phosphate　(CQP),　commonly　used　in　treating　autoimmune　diseases　and　malaria,　has　been　detected　in　various　water　bodies　and　poses　potential　hazards　to　the　ecological　environment.　In　this　study,　ZIF-67-derived　Co　3　S　4　-modified　graphite　felt　cathode　(Co　3　S　4　/GF)　was　used　to　construct　a　heterogeneous　electro-Fenton　system　for　efficient　CQP　removal.　The　introduction　of　sulfur　greatly　improved　the　electron　transfer　rate　and　reduced　the　charge　transfer　resistance,　garnering　the　Co　3　S　4　/GF　composite　cathode　with　excellent　electrochemical　activity.　The　Co　3　S　4　/GF　electro-Fenton　system　completely　removed　CQP　within　60　min　at　near　-neutral　initial　pH　and　exhibited　19.3　%　higher　CQP　removal　efficiency　than　the　ZIF-67/GF　system.　This　enhanced　performance　was　mainly　attributed　to　the　introduction　of　sulfur,　which　increased　the　proportion　of　low-valent　metal　in　the　material　and　promoted　the　Co　III　and　Co　II　cycle.　The　hydroxyl　radical　was　identified　as　the　main　radical　involved　in　CQP　degradation.　The　intermediates　of　CQP　degradation　were　detected,　and　four　possible　degradation　pathways　of　CQP　were　obtained.　The　ecotoxicity　of　CQP　and　its　intermediates　decreased　during　the　degradation　process.　This　work　proposes　novel　ideas　for　the　rapid　development　of　metal　-organic　framework　-derived　Co/S-based　materials　for　their　application　in　the　field　of　environmental　catalysis.