Static　pipeline　mixers　play　a　crucial　role　in　water　treatment　processes,　and　their　mixing　efficiency　can　be　influenced　by　factors.　Innovating　mixer　design　to　simultaneously　reduce　head　loss　and　G-values　while　maintaining　effective　mixing　across　various　flow　conditions　holds　practical　significance　for　improving　treatment　process　performance.　This　study　used　a　combination　of　numerical　simulations　and　experimental　validation　to　investigate　the　mixing　process　of　a　novel　multi-stage　static　pipeline　mixer.　The　results　indicated　that　within　the　flow　velocity　range　of　0.2-1.8　m/s,　compared　to　the　Kenics　mixer,　the　new　multi-stage　static　pipeline　mixers　(HOCM　and　COCM)　achieved　significant　reductions　in　head　loss　(89.4　%　for　HOCM　and　52.9　%　for　COCM)　and　Gvalues　(67.3　%　for　HOCM　and　31.3　%　for　COCM).　The　turbulent　kinetic　energy　intensity　of　HOCM　was　much　lower　than　that　of　COCM　and　Kenics　mixers.　Importantly,　all　mixers　reached　a　state　of　complete　mixing　with　the　coefficient　of　variation　(CoV)　less　than　0.05.　In　the　HOCM　mixer,　the　2nd　mixing　stage　was　identified　as　the　primary　mixing　zone,　while　in　the　COCM　mixer,　the　1st　mixing　stage　played　a　crucial　role　in　mixing.　When　the　mixers　achieved　a　mixing　degree　of　95　%,　the　head　loss　of　HOCM　and　COCM　was　significantly　lower　than　various　types　of　traditional　mixers　(Kenics,　SMX,　SMV,　ISG,　Inliner　Lightnin).　This　is　attributed　to　the　highly　efficient　mixing　effect　generated　by　the　clockwise　helical　flow　produced　in　the　1st　and　2nd　mixing　stages.