The　pursuit　of　highly　active　oxygen　evolution　reaction　(OER)　catalysts,　especially　those　free　of　noble　metals,　is　a　focal　point　in　fuel　cell　research.　Utilizing　extensive　density　functional　theory　calculations,　this　study　designed　and　evaluated　the　activity　and　stability　of　single-atom　catalysts　(SACs)　composed　of　3d,　4d　and　5d　transition　metals　supported　on　tungsten-based　MXene　for　OER　applications.　Results　highlighted　the　exceptional　OER　performance　of　Ni@W2CO2,　Rh@W2CO2　and　Pt@W2CO2,　displaying　remarkably　low　overpotentials.　The　catalytic　activity　of　TM@W2CO2　SACs　exhibited　a　robust　correlation　with　surface　properties,　particularly　the　d-band　center　index　and　surface　work　function.　Moreover,　Ni@W2CO2,　Rh@W2CO2　and　Pt@W2CO2　emerged　as　promising　candidates　for　OER　and　oxygen　reduction　reaction　(ORR)　bifunctional　catalysis,　while　Pt@W2CO2　and　Rh@W2CO2　showed　high　potential　for　OER　and　hydrogen　evolution　reaction　(HER)　bifunctional　catalysis.　The　effectiveness　of　tungsten-based　MXene　as　a　substrate　for　non-noble-metal　SACs　marks　a　breakthrough　in　OER　catalyst　design,　driving　advancements　towards　sustainable　energy　solutions　and　addressing　critical　challenges　in　energy　conversion　and　storage.