Ambitious　action　plans　have　been　launched　to　address　climate　change　and　air　pollution.　Through　coupling　the　IMED|CGE,　GAINS,　and　IMED|HEL　models,　this　study　investigate　the　impacts　of　implementing　carbon　neutrality　and　clean　air　policies　on　the　energy　-environment　-health　-economy　chain　in　the　Beijing　-TianjinHebei　-Henan　-Shandong　-Shanxi　region　of　China.　Results　show　that　Shandong　holds　the　largest　reduction　in　energy　consumption　and　carbon　emissions　toward　the　1.5　degrees　C　target.　Shandong,　Henan,　and　Hebei　are　of　particularly　prominent　pollutant　reduction　potential.　Synergistic　effects　of　carbon　reduction　on　decreasing　PM　2.5　concentration　will　increase　in　the　future,　specifically　in　energy　-intensive　regions.　Codeployment　of　carbon　reduction　and　end　-of　-pipe　technologies　are　beneficial　to　decrease　PM　2.5　-related　mortalities　and　economic　loss　by　4.7-12.9%　in　2050.　Provincial　carbon　reduction　cost　will　be　higher　than　monetary　health　benefits　after　2030,　indicating　that　more　zero　-carbon　technologies　should　be　developed.　Our　findings　provide　scientific　enlightenment　on　policymaking　toward　achieving　carbon　reduction　and　pollution　mitigation　from　multiple　perspectives.