This　paper　researched　the　membrane　filtration　behavior　and　mechanism　of　the　PAN　Microfiltration　(MF)　membrane　fouled　with　the　model　binary/ternary　mixture　of　extracellular　polymer　substance　(EPS)　solution　under　various　model　mixture　solution　type.　The　research　indicated　that　the　fouling　mechanism　at　the　beginning　of　the　model　binary　mixture　(BSA + SA/BSA + HA/SA + HA)　is　the　combined　mechanism　(pore　blocking-cake　filtration),　the　fouling　mechanism　in　the　latter　stage　of　the　model　binary　mixture　(HA + SA)　is　only　the　cake　filtration.　The　fouling　mechanism　of　the　model　ternary　mixture　(BSA + HA + SA)　is　the　combined　mechanism　(pore　blocking-cake　filtration).　Meanwhile,　SA　plays　an　vital　role　in　the　change　of　filtration　quality　in　the　model　binary/ternary　mixture　system,　while　HA　and　BSA　have　less　effect.　In　addition,　increasing　the　HA/SA　density　in　the　model　ternary　mixture　can　aggravate　the　occurrence　of　membrane　fouling,　while　increasing　the　BSA　density　in　the　model　ternary　mixture　can　alleviate　the　occurrence　of　membrane　fouling.　©　The　Author(s),　under　exclusive　license　to　Springer　Nature　Switzerland　AG　2024.