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Author:

Ma, Zi-Yu (Ma, Zi-Yu.) | Sun, Shen (Sun, Shen.) | Wu, Shui-Cai (Wu, Shui-Cai.) | Lin, Lan (Lin, Lan.) | Chen, Yi-Xiong (Chen, Yi-Xiong.) | Zhao, Dong (Zhao, Dong.) | Morgan, Stephen P. (Morgan, Stephen P..)

Indexed by:

Scopus SCIE

Abstract:

Purpose: Capillary Refill Time (CRT) measurement has gained increasing attention in the field of sepsis and septic shock. Recognizing pressure as a fundamental determinant in CRT measurement is crucial for establishing a standardized CRT measurement procedure. In this preliminary study, we elucidated the optimal pressing strength for CRT measurement by analyzing the CRTs measured under varying pressures. Method: Seventeen healthy individuals were enlisted to undergo CRT tests on their fingertips at various pressure levels. The applied force was initiated at 0.5N and incrementally increased by 0.5N until it reached 10.5N. An integrated Photoplethysmography (PPG) device was employed to capture fluctuations in light intensity. The CRT was automatically derived from the PPG signals via a specialized algorithm. The study included correlation assessment and reliability evaluation. Box plot and Bland-Altman plot were used to visualize the impact of pressure levels on CRTs. Results: A dataset of 1414 CRTs across 21 pressures showed significant differences (Kruskal-Wallis test, p < 0.0001), highlighting the impact of pressure on CRT. CRT values between 4.5N and 10.5N pressures varied less, with an Intraclass Correlation Coefficient (ICC) of 0.499 indicating moderate consistency. Notably, CRTs at 10N and 10.5N pressures revealed a high ICC of 0.790, suggesting strong agreement. Conclusion: A pressure range of 4.5N-10.5N is recommended for stable CRT measurements, with 10.0N-10.5N providing optimal consistency and reliability.

Keyword:

Pressure Microcirculation Capillary refill time Sepsis Septic shock

Author Community:

  • [ 1 ] [Ma, Zi-Yu]Beijing Univ Technol, Fac Environm & Life, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 2 ] [Sun, Shen]Beijing Univ Technol, Fac Environm & Life, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 3 ] [Wu, Shui-Cai]Beijing Univ Technol, Fac Environm & Life, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 4 ] [Lin, Lan]Beijing Univ Technol, Fac Environm & Life, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 5 ] [Chen, Yi-Xiong]Beijing Sci & Technol Project Manager Management C, Beijing, Peoples R China
  • [ 6 ] [Zhao, Dong]Capital Med Univ, Beijing Luhe Hosp, Dept Endocrinol, Beijing, Peoples R China
  • [ 7 ] [Morgan, Stephen P.]Univ Nottingham, Opt & Photon Res Grp, Nottingham, England

Reprint Author's Address:

  • [Sun, Shen]100 Pingleyuan, Beijing 100124, Peoples R China;;

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Source :

HELIYON

Year: 2024

Issue: 15

Volume: 10

4 . 0 0 0

JCR@2022

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 5

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