The　dynamic　interaction　between　tunnels　and　adjacent　buildings　under　seismic　action　is　a　complex　issue　in　ensuring　the　earthquake　resistance　of　modern　infrastructure.　The　seismic　response　of　an　entire　system　poses　significant　challenges　in　the　structural　design　and　safe　operation.　To　study　the　seismic　response　law　of　tunnels　(single　and　double)　passing　below　a　surface　frame　structure　containing　a　basement,　this　study　designed　and　conducted　a　series　of　shaking　table　tests　based　on　an　actual　project　in　which　tunnels　pass　at　under　and　side-　through　positions　relative　to　an　office　building　in　Zhengzhou,　China.　The　results　showed　that　the　frame　structure　amplified　the　acceleration　responses　of　the　soil　and　tunnel,　while　the　tunnel　reduced　the　acceleration　response　of　the　nearby　tunnel　and　frame　structure,　and　the　basement　decreased　the　acceleration　response　of　the　first-floor　slab;　the　frame　structure　and　tunnel　amplified　the　strain　response　of　nearby　tunnels;　the　tunnel　had　an　amplifying　effect　on　the　inter-story　drift　ratio　of　the　frame　structures　above　the　weak　layers　and　a　reducing　effect　below　the　weak　layers.　Neither　the　variation　in　the　seismic　wave　amplitude　nor　the　presence　of　the　tunnel　altered　the　location　of　the　weak　layers　in　the　frame　structure.　The　type　of　seismic　wave　and　the　location　of　the　tunnel　crossing　had　a　certain　impact　on　the　seismic　response　of　the　structural　systems.