Direct　liquid　fuel　cells(DLFCs)are　promising　clean　energy　conversion　devices　for　their　high　energy　density,low　environmental　pollution,and　convenient　transportation　and　storage.However,the　commercialization　of　DLFCs　is　still　limited　by　the　lack　of　highly　active　and　stable　catalysts　for　the　anodic　oxidation　of　liquid　fuels.Herein,a　new　class　of　ultrathin　PtRu　nanowires(NWs)with　a　diameter　of　1.1nm　was　synthesized　via　a　colloidal　chemistry　strategy.The　as-made　ultrathin　PtRu　NWs　can　not　only　expose　large　active　sites　but　also　enhance　the　kinetics　of　methanol　oxidation　reaction,which　was　confirmed　by　the　in　situ　Fourier　transform　infrared(FTIR)spectroscopy.Consequently,ultrathin　PtRu　NWs　exhibit　greatly　boosted　activity　and　stability　for　methanol　and　ethanol　oxidation　reactions　in　an　alkaline　medium.