This　study　investigated　the　effectiveness　of　the　nanoconfined　catalytic　membrane　(NCCM),　fabricated　by　nitrogen-doped　carbon　nanotubes　(NCNT)　incorporated　with　graphene　oxide　membrane　(NCNT@GO-M),　in　mitigating　fouling　caused　by　effluent　organic　matter　(EfOM).　Compared　to　conventional　catalytic　membranes　(NRCM)　that　lack　precise　spatial　design　and　prepared　with　only　NCNT,　NCCM　exhibits　a　unique　advantage　by　preferentially　retaining　and　adsorbing　protein-like　substances　in　EfOM　during　the　fouling　formation　process,　forming　a　cake　layer　that　effectively　mitigates　pore　blockage　from　irreversible　foulants.　Furthermore,　the　ordered　nanoconfined　structure　of　NCCM　facilitates　an　intelligent　＂pore-centric＂　hierarchical　degradation　strategy　based　on　the　molecular　size　of　EfOM,　preferentially　removing　irreversible　foulants　caused　by　fulvic　acid-like　and　low　molecular　weight　protein-like　substances.　The　results　demonstrated　effective　preservation　of　catalytic　sites　by　the　NCCM＇s　advanced　nanoconfined　configuration　and　a　1.6-fold　increase　in　the　mass　transfer　rate　of　peroxymonosulfate　(PMS)　compared　to　NRCM,　synergistically　promoting　hydroxyl　radical　(center　dot　OH)　enrichment,　resulting　in　rapid　EfOM　degradation　kinetics.　Additionally,　chemical　cleaning　almost　completely　eliminated　irreversible　fouling,　restoring　the　NCCM　to　near　its　original　flux.　Overall,　this　study　sheds　light　on　the　fouling　mitigation　mechanisms　of　NCCM,　aiding　their　tailored　design　and　application　in　targeted　wastewater　treatment.