A　highly　effective　synthetic　clinoptilolite　(SCP)　was　developed　and　assessed　for　its　potential　in　the　simultaneous　removal　of　Cd2+,　Ni2+,　Mn2+,　Sr2+,　and　Fe3+　from　an　aqueous　solution.　The　present　work　explored　the　influences　of　SCP　dosage,　initial　metal　ion　concentrations,　temperature,　contact　time,　and　pH　value　on　the　adsorption　performances　of　these　metal　ions.　The　results　revealed　exceptionally　high　adsorption　capacities,　reaching　2000,　1720,　1875,　1510,　and　22　mg/g　for　Ni2+,　Fe3+,　Cd2+,　Mn2+,　and　Sr2+,　respectively.　The　specific　surface　area　of　SCP　increased　from　31.4　to　44.7　m2/g　after　five　cycles.　The　adsorption　mechanism　and　structure　assessment　were　elucidated　by　XRD　patterns　and　SEM　images,　showing　that　the　Fe3+　adsorption　conformed　to　the　Langmuir　isotherm,　while　that　of　Mn2+,　Cd2+,　Sr2+,　and　Ni2+　followed　the　Freundlich　isotherm　model　with　the　adsorption　kinetics　best　described　by　the　pseudo-2nd-order　kinetic　model.　Thermodynamic　parameters　showed　endothermic　behavior　for　Cd2+,　Ni2+,　Mn2+,　and　Sr2+,　exothermic　for　Fe3+,　and　spontaneity　for　all　metals　except　Sr2+.　SCP　retained　over　90　%　of　its　adsorption　capacity　after　five　regeneration　cycles,　maintaining　structural　integrity　under　thermal,　acidic,　and　recycling　conditions.　These　findings　highlight　SCP＇s　robust　characteristics,　reusability,　and　potential　for　sustainable　heavy　metal　removal　from　wastewater.　©　2024　Elsevier　Ltd